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Issue 5, 2016
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Aqueous phase preparation of ultrasmall MoSe2 nanodots for efficient photothermal therapy of cancer cells

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Abstract

Photothermal therapy (PTT) is a promising cancer treatment with both high effectiveness and fewer side effects. However, an ideal PTT agent not only needs strong absorption of near-infrared (NIR) light and high photothermal conversion efficiency, but also needs good biocompatibility, stability, and small size, which makes the design and preparation of a novel PTT agent a great challenge. In this work, we developed an ultrasonication-assisted liquid exfoliation method for the direct preparation of ultrasmall (2–3 nm) MoSe2 nanodots (NDs) in aqueous solution and demonstrated their superior properties as a PTT agent. The as-prepared MoSe2 NDs have strong absorption of NIR light and high photothermal conversion efficiency of about 46.5%. In vitro cellular experiments demonstrate that MoSe2 NDs have negligible cytotoxicity and can efficiently kill HeLa cells (human cervical cell line) under NIR laser (785 nm) irradiation.

Graphical abstract: Aqueous phase preparation of ultrasmall MoSe2 nanodots for efficient photothermal therapy of cancer cells

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Publication details

The article was received on 18 Nov 2015, accepted on 22 Dec 2015 and first published on 22 Dec 2015


Article type: Paper
DOI: 10.1039/C5NR08166A
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Citation: Nanoscale, 2016,8, 2720-2726

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    Aqueous phase preparation of ultrasmall MoSe2 nanodots for efficient photothermal therapy of cancer cells

    L. Yuwen, J. Zhou, Y. Zhang, Q. Zhang, J. Shan, Z. Luo, L. Weng, Z. Teng and L. Wang, Nanoscale, 2016, 8, 2720
    DOI: 10.1039/C5NR08166A

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