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Issue 6, 2016

Smart conjugated polymer nanocarrier for healthy weight loss by negative feedback regulation of lipase activity

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Abstract

Healthy weight loss represents a real challenge when obesity is increasing in prevalence. Herein, we report a conjugated polymer nanocarrier for smart deactivation of lipase and thus balancing calorie intake. After oral administration, the nanocarrier is sensitive to lipase in the digestive tract and releases orlistat, which deactivates the enzyme and inhibits fat digestion. It also creates negative feedback to control the release of itself. The nanocarrier smartly regulates activity of the lipase cyclically varied between high and low levels. In spite of high fat diet intervention, obese mice receiving a single dose of the nanocarrier lose weight over eight days, whereas a control group continues the tendency to gain weight. Daily intragastric administration of the nanocarrier leads to lower weight of livers or fat pads, smaller adipocyte size, and lower total cholesterol level than that of the control group. Near-infrared fluorescence of the nanocarrier reveals its biodistribution.

Graphical abstract: Smart conjugated polymer nanocarrier for healthy weight loss by negative feedback regulation of lipase activity

Supplementary files

Article information


Submitted
28 Sep 2015
Accepted
28 Dec 2015
First published
04 Jan 2016

Nanoscale, 2016,8, 3368-3375
Article type
Paper

Smart conjugated polymer nanocarrier for healthy weight loss by negative feedback regulation of lipase activity

Y. Chen, S. Zhu, L. Zhang, P. Feng, X. Yao, C. Qian, C. Zhang, X. Jiang and Q. Shen, Nanoscale, 2016, 8, 3368 DOI: 10.1039/C5NR06721A

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