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Issue 2, 2016
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Gd-based upconversion nanocarriers with yolk–shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

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Abstract

Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk–shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk–shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core–shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk–shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer.

Graphical abstract: Gd-based upconversion nanocarriers with yolk–shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

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Publication details

The article was received on 22 Sep 2015, accepted on 22 Nov 2015 and first published on 23 Nov 2015


Article type: Paper
DOI: 10.1039/C5NR06522D
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Citation: Nanoscale, 2016,8, 878-888

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    Gd-based upconversion nanocarriers with yolk–shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

    Y. Pan, L. Zhang, L. Zeng, W. Ren, X. Xiao, J. Zhang, L. Zhang, A. Li, G. Lu and A. Wu, Nanoscale, 2016, 8, 878
    DOI: 10.1039/C5NR06522D

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