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Issue 48, 2015

Reconfigurable and resettable arithmetic logic units based on magnetic beads and DNA

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Abstract

Based on the characteristics of magnetic beads and DNA, a simple and universal platform was developed for the integration of multiple logic gates to achieve resettable half adder and half subtractor functions. The signal reporter was composed of a split G-quadruplex DNAzyme and AuNP-surface immobilized molecular beacon molecule. The novel feature of the designed system is that the inputs (split G-quadruplexes) can interact with hairpin-modified Au NPs linked to magnetic particles. Another novel feature is that the logic operations can be reset by heating the output system and by using the magnetic separation of the computing modules. Moreover, the developed half adder and half subtractor are realized on a simple DNA/magnetic bead platform in an enzyme-free system and share a constant threshold setpoint. Due to the diversity and design flexibility of DNA, these investigations may provide a new method for the development of resettable DNA-based arithmetic operations.

Graphical abstract: Reconfigurable and resettable arithmetic logic units based on magnetic beads and DNA

Supplementary files

Article information


Submitted
29 Sep 2015
Accepted
11 Nov 2015
First published
12 Nov 2015

Nanoscale, 2015,7, 20749-20756
Article type
Paper

Reconfigurable and resettable arithmetic logic units based on magnetic beads and DNA

S. Zhang, K. Wang, C. Huang and T. Sun, Nanoscale, 2015, 7, 20749 DOI: 10.1039/C5NR06733B

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