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Issue 40, 2015

Microgel coating of magnetic nanoparticles via bienzyme-mediated free-radical polymerization for colorimetric detection of glucose

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Abstract

This study describes a new strategy for the fabrication of magnetic core–shell microgels by free-radical polymerization triggered by the cascade reaction of glucose oxidase (GOx) and horseradish peroxidase (HRP). The mild polymerization around the interface of the magnetic nanoparticles permits the mild coating of the microgel layer with excellent characteristics for various applications in biocatalysis and medical diagnostics, as well as in clinical fields. The immobilized bienzyme within the microgel has a largely retained activity relative to the non-immobilized one. The confining effect of the microgel and the well designed distance between the two enzymes can benefit the diffusion of intermediates to the HRP active site. The final microgels can be incontestably employed as sensitive biosensors for colorimetric glucose detection.

Graphical abstract: Microgel coating of magnetic nanoparticles via bienzyme-mediated free-radical polymerization for colorimetric detection of glucose

Supplementary files

Article information


Submitted
23 Aug 2015
Accepted
11 Sep 2015
First published
14 Sep 2015

Nanoscale, 2015,7, 16578-16582
Article type
Communication

Microgel coating of magnetic nanoparticles via bienzyme-mediated free-radical polymerization for colorimetric detection of glucose

Q. Wu, X. Wang, C. Liao, Q. Wei and Q. Wang, Nanoscale, 2015, 7, 16578 DOI: 10.1039/C5NR05716G

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