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Issue 42, 2015
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Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

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Abstract

Nanoparticle (NP)-based combination chemotherapy has been proposed as an effective strategy for achieving synergistic effects and targeted drug delivery for colon cancer therapy. Here, we fabricated a series of hyaluronic acid (HA)-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs (HA-CPT/CUR-NPs) with various weight ratios of CPT to CUR (1 : 1, 2 : 1 and 4 : 1). The resultant spherical HA-CPT/CUR-NPs had a desirable particle size (around 289 nm), relative narrow size distribution, and slightly negative zeta potential. These NPs exhibited a simultaneous sustained release profile for both drugs throughout the time frame examined. Subsequent cellular uptake experiments demonstrated that the introduction of HA to the NP surface endowed NPs with colon cancer-targeting capability and markedly increased cellular uptake efficiency compared with chitosan-coated NPs. Importantly, the combined delivery of CPT and CUR in one HA-functionalized NP exerted strong synergistic effects. HA-CPT/CUR-NP (1 : 1) showed the highest antitumor activity among the three HA-CPT/CUR-NPs, resulting in an extremely low combination index. Collectively, our findings indicate that this HA-CPT/CUR-NP can be exploited as an efficient formulation for colon cancer-targeted combination chemotherapy.

Graphical abstract: Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

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Supplementary files

Article information


Submitted
19 Jul 2015
Accepted
28 Sep 2015
First published
05 Oct 2015

Nanoscale, 2015,7, 17745-17755
Article type
Paper

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

B. Xiao, M. K. Han, E. Viennois, L. Wang, M. Zhang, X. Si and D. Merlin, Nanoscale, 2015, 7, 17745
DOI: 10.1039/C5NR04831A

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