Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 33, 2015
Previous Article Next Article

Accelerating peroxidase mimicking nanozymes using DNA

Author affiliations


DNA-capped iron oxide nanoparticles are nearly 10-fold more active as a peroxidase mimic for TMB oxidation than naked nanoparticles. To understand the mechanism, the effect of DNA length and sequence is systematically studied, and other types of polymers are also compared. This rate enhancement is more obvious with longer DNA and, in particular, poly-cytosine. Among the various polymer coatings tested, DNA offers the highest rate enhancement. A similar acceleration is also observed for nanoceria. On the other hand, when the positively charged TMB substrate is replaced by the negatively charged ABTS, DNA inhibits oxidation. Therefore, the negatively charged phosphate backbone and bases of DNA can increase TMB binding by the iron oxide nanoparticles, thus facilitating the oxidation reaction in the presence of hydrogen peroxide.

Graphical abstract: Accelerating peroxidase mimicking nanozymes using DNA

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jun 2015, accepted on 16 Jul 2015 and first published on 22 Jul 2015

Article type: Communication
DOI: 10.1039/C5NR04176G
Citation: Nanoscale, 2015,7, 13831-13835

  •   Request permissions

    Accelerating peroxidase mimicking nanozymes using DNA

    B. Liu and J. Liu, Nanoscale, 2015, 7, 13831
    DOI: 10.1039/C5NR04176G

Search articles by author