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Issue 40, 2015
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Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery

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Abstract

Translation of therapeutic polymeric nanosystems to patients and industry requires simplified, reproducible and scalable methods for assembly and loading. A single-step in-line process based on nanocoprecipitation of oxazoline-siloxane block copolymers in flow-focusing poly(dimethylsiloxane) microfluidics was designed to manufacture injection-ready nanosystems. Nanosystem characteristics could be controlled by copolymer concentration, block length and chemistry, microchannel geometry, flow rate, aqueous/organic flow rate ratio and payload concentration. The well-tolerated nanosystems exhibited differential cell binding and payload delivery and could confer sensitivity to photodynamic therapy to HeLa cancer cells. Such injection-ready nanosystems carrying drugs, diagnostic or functional materials may facilitate translation to clinical application.

Graphical abstract: Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery

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Article information


Submitted
29 May 2015
Accepted
12 Sep 2015
First published
21 Sep 2015

Nanoscale, 2015,7, 16983-16993
Article type
Paper

Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery

K. Liu, Z. Zhu, X. Wang, D. Gonçalves, B. Zhang, A. Hierlemann and P. Hunziker, Nanoscale, 2015, 7, 16983
DOI: 10.1039/C5NR03543K

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