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Issue 37, 2015
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Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

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Abstract

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

Graphical abstract: Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

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Supplementary files

Article information


Submitted
10 May 2015
Accepted
26 Jun 2015
First published
30 Jun 2015

Nanoscale, 2015,7, 15046-15050
Article type
Communication
Author version available

Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev, J. G. Croissant, K. Julfakyan, L. Deng, D. H. Anjum, A. Gurinov and N. M. Khashab, Nanoscale, 2015, 7, 15046
DOI: 10.1039/C5NR03065J

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