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Issue 37, 2015
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Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

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Abstract

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

Graphical abstract: Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

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Publication details

The article was received on 10 May 2015, accepted on 26 Jun 2015 and first published on 30 Jun 2015


Article type: Communication
DOI: 10.1039/C5NR03065J
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Citation: Nanoscale, 2015,7, 15046-15050

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    Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

    Y. Fatieiev, J. G. Croissant, K. Julfakyan, L. Deng, D. H. Anjum, A. Gurinov and N. M. Khashab, Nanoscale, 2015, 7, 15046
    DOI: 10.1039/C5NR03065J

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