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Issue 30, 2015
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Reduction-sensitive polymeric nanocarriers in cancer therapy: a comprehensive review

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Abstract

Redox potential is regarded as a significant signal to distinguish between the extra-cellular and intra-cellular environments, as well as between tumor and normal tissues. Taking advantage of this physiological differentiation, various reduction-sensitive polymeric nanocarriers (RSPNs) have been designed and explored to demonstrate excellent stability during blood circulation but rapidly degrade and effectively trigger drug release in tumor cells. Therefore, this smart RSPN delivery system has attracted much attention in recent years, as it represents one of the most promising drug delivery strategies in cancer therapy. In this review, we will provide a comprehensive overview of RSPNs with various reducible linkages and functional groups up to date, including their design and synthetic strategies, preparation methods, drug release behavior, and their in vitro and in vivo efficacy in cancer therapy. In addition, dual- and triple-sensitive nanocarriers based on reducible disulfide bond-containing linkages will also be discussed.

Graphical abstract: Reduction-sensitive polymeric nanocarriers in cancer therapy: a comprehensive review

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Publication details

The article was received on 03 May 2015, accepted on 26 Jun 2015 and first published on 02 Jul 2015


Article type: Review Article
DOI: 10.1039/C5NR02878G
Nanoscale, 2015,7, 12773-12795

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    Reduction-sensitive polymeric nanocarriers in cancer therapy: a comprehensive review

    B. Deng, P. Ma and Y. Xie, Nanoscale, 2015, 7, 12773
    DOI: 10.1039/C5NR02878G

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