Issue 29, 2015

An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates

Abstract

Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.

Graphical abstract: An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates

Article information

Article type
Paper
Submitted
29 Apr 2015
Accepted
14 Jun 2015
First published
16 Jun 2015

Nanoscale, 2015,7, 12614-12624

Author version available

An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates

L. Zhang, Y. Li, Z. Jin, J. C. Yu and K. M. Chan, Nanoscale, 2015, 7, 12614 DOI: 10.1039/C5NR02767E

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