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Issue 29, 2015
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Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides

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Abstract

Dendrimer-based gene delivery has been constrained by intrinsic toxicity and suboptimal nanostructure. Conjugation of neutral morpholino oligonucleotides (ONs) with PAMAM dendrimers resulted in neutral, uniform, and ultra-small (∼10 nm) nanoconjugates. The nanoconjugates dramatically enhanced cellular delivery of the ONs in cancer cells. After release from the dendrimer in the cytosol, the ONs produced potent functional activity without causing significant cytotoxicity. When carrying an apoptosis-promoting ON, the nanoconjugates produced cancer cell killing directly. Thus, the dendritic nanoconjugates may provide an effective tool for delivering ONs to tumors and other diseased tissues.

Graphical abstract: Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides

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Publication details

The article was received on 14 Mar 2015, accepted on 16 Jun 2015 and first published on 23 Jun 2015


Article type: Communication
DOI: 10.1039/C5NR01665G
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Citation: Nanoscale, 2015,7, 12302-12306

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    Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides

    X. Ming, L. Wu, K. Carver, A. Yuan and Y. Min, Nanoscale, 2015, 7, 12302
    DOI: 10.1039/C5NR01665G

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