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Issue 28, 2015
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Investigation of cyano-bridged coordination nanoparticles Gd3+/[Fe(CN)6]3−/d-mannitol as T1-weighted MRI contrast agents

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Abstract

Cyano-bridged Gd3+/[Fe(CN)6]3− coordination polymer nanoparticles of 3–4 nm stabilized with D-mannitol presenting a high r1 relaxivity value of 11.4 mM−1 s−1 were investigated in vivo as contrast agents (CA) for Magnetic Resonance Imaging (MRI). They allow an increase of the MR image contrast and can act as an efficient intravascular T1 CA with a relatively long blood-circulation lifetime (60 min) without specific toxicity.

Graphical abstract: Investigation of cyano-bridged coordination nanoparticles Gd3+/[Fe(CN)6]3−/d-mannitol as T1-weighted MRI contrast agents

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Supplementary files

Article information


Submitted
10 Mar 2015
Accepted
27 Apr 2015
First published
28 Apr 2015

Nanoscale, 2015,7, 11899-11903
Article type
Communication
Author version available

Investigation of cyano-bridged coordination nanoparticles Gd3+/[Fe(CN)6]3−/D-mannitol as T1-weighted MRI contrast agents

M. Perrier, A. Gallud, A. Ayadi, S. Kennouche, C. Porredon, M. Gary-Bobo, J. Larionova, Ch. Goze-Bac, M. Zanca, M. Garcia, I. Basile, J. Long, J. de Lapuente, M. Borras and Y. Guari, Nanoscale, 2015, 7, 11899
DOI: 10.1039/C5NR01557J

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