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Issue 9, 2015
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Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

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Abstract

The well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like derivatives affording novel nanodevices showing moderate to strong antiproliferative activities against liquid and solid tumor cell lines, respectively.

Graphical abstract: Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

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The article was received on 10 Oct 2014, accepted on 26 Nov 2014 and first published on 01 Dec 2014


Article type: Paper
DOI: 10.1039/C4NR05983B
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Citation: Nanoscale, 2015,7, 3915-3922

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    Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

    N. El Brahmi, S. M. Mignani, J. Caron, S. El Kazzouli, M. M. Bousmina, A. Caminade, T. Cresteil and J. Majoral, Nanoscale, 2015, 7, 3915
    DOI: 10.1039/C4NR05983B

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