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Issue 21, 2014
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Enzyme-responsive nanomaterials for controlled drug delivery

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Enzymes underpin physiological function and exhibit dysregulation in many disease-associated microenvironments and aberrant cell processes. Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials used for controlled drug release have achieved significant development and have been studied as an important class of drug delivery strategies in nanomedicine. In this review, we describe enzymes such as proteases, phospholipases and oxidoreductases that serve as delivery triggers. Subsequently, we explore recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. We conclude by discussing future opportunities and challenges in this area.

Graphical abstract: Enzyme-responsive nanomaterials for controlled drug delivery

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Publication details

The article was received on 27 Jul 2014, accepted on 02 Sep 2014 and first published on 24 Sep 2014

Article type: Feature Article
DOI: 10.1039/C4NR04249B
Nanoscale, 2014,6, 12273-12286

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    Enzyme-responsive nanomaterials for controlled drug delivery

    Q. Hu, P. S. Katti and Z. Gu, Nanoscale, 2014, 6, 12273
    DOI: 10.1039/C4NR04249B

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