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Issue 19, 2014
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Combined photothermal and photodynamic therapy delivered by PEGylated MoS2 nanosheets

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Abstract

Single- or few-layered transitional metal dichalcogenides, as a new genus of two-dimensional nanomaterials, have attracted tremendous attention in recent years, owing to their various intriguing properties. In this study, chemically exfoliated MoS2 nanosheets are modified with lipoic acid-terminated polyethylene glycol (LA-PEG), obtaining PEGylated MoS2 (MoS2-PEG) with high stability in physiological solutions and no obvious toxicity. Taking advantage of its ultra-high surface area, the obtained MoS2-PEG is able to load a photodynamic agent, chlorin e6 (Ce6), by physical adsorption. In vitro experiments reveal that Ce6 after being loaded on MoS2-PEG shows remarkably increased cellular uptake and thus significantly enhanced photodynamic therapeutic efficiency. Utilizing the strong, near-infrared (NIR) absorbance of the MoS2 nanosheets, we further demonstrate photothermally enhanced photodynamic therapy using Ce6-loaded MoS2-PEG for synergistic cancer killing, in both in vitro cellular and in vivo animal experiments. Our study presents a new type of multifunctional nanocarrier for the delivery of photodynamic therapy, which, if combined with photothermal therapy, appears to be an effective therapeutic approach for cancer treatment.

Graphical abstract: Combined photothermal and photodynamic therapy delivered by PEGylated MoS2 nanosheets

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Publication details

The article was received on 05 Jul 2014, accepted on 21 Jul 2014 and first published on 25 Jul 2014


Article type: Paper
DOI: 10.1039/C4NR03753G
Citation: Nanoscale, 2014,6, 11219-11225
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    Combined photothermal and photodynamic therapy delivered by PEGylated MoS2 nanosheets

    T. Liu, C. Wang, W. Cui, H. Gong, C. Liang, X. Shi, Z. Li, B. Sun and Z. Liu, Nanoscale, 2014, 6, 11219
    DOI: 10.1039/C4NR03753G

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