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Issue 19, 2014
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Exploitable length correlations in peptide nanofibres

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Abstract

Sequence-prescribed biomolecular assemblies find increasing use in the development of novel nanostructured materials. Critical requirements for emerging designs remain in matching form with function. Peptide assembly diversifies form and supports function, but lacks control over both. Herein we exploit length correlations in peptide nanoscale fibres (form) using a model helical template. We establish that different assembly patterns result from a synergistic interplay between peptide length, net charge and folding and supra-molecular cooperativity, while correlating with increases in cell proliferation (function) as a function of peptide length. The revealed correlations offer an efficient rationale for the programming of longitudinally finite and biologically active nanoscale fibres.

Graphical abstract: Exploitable length correlations in peptide nanofibres

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Supplementary files

Article information


Submitted
16 Jun 2014
Accepted
11 Aug 2014
First published
13 Aug 2014

Nanoscale, 2014,6, 11425-11430
Article type
Paper
Author version available

Exploitable length correlations in peptide nanofibres

E. De Santis, N. Faruqui, J. E. Noble and M. G. Ryadnov, Nanoscale, 2014, 6, 11425
DOI: 10.1039/C4NR03328K

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