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Issue 13, 2014
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DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

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Abstract

Gold nanoparticles (GNPs) can be used as carriers of a variety of therapeutics. Ideally, drugs are released in the target cells in response to cell specific intracellular triggers. In this study, GNPs are loaded with doxorubicin or AZD8055, using a self-immolative linker which facilitates the release of anticancer therapeutics in malignant cells without modifications of the active compound. An additional modification with the aptamer AS1411 further increases the selectivity of GNPs towards cancer cells. Both modifications increase targeted delivery of therapeutics with GNPs. Whereas GNPs without anticancer drugs do not affect cell viability in all cells tested, AS1411 modified GNPs loaded with doxorubicin or AZD8055 show significant and increased reduction of cell viability in breast cancer and uveal melanoma cell lines. These results highlight that modified GNPs can be functionalized to increase the efficacy of cancer therapeutics and may further reduce toxicity by increasing targeted delivery towards malignant cells.

Graphical abstract: DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

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Supplementary files

Article information


Submitted
02 Jan 2014
Accepted
19 Apr 2014
First published
22 Apr 2014

Nanoscale, 2014,6, 7436-7442
Article type
Paper
Author version available

DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

A. Latorre, C. Posch, Y. Garcimartín, A. Celli, M. Sanlorenzo, I. Vujic, J. Ma, M. Zekhtser, K. Rappersberger, S. Ortiz-Urda and Á. Somoza, Nanoscale, 2014, 6, 7436
DOI: 10.1039/C4NR00019F

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