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Issue 12, 2014
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Enhancing endosomal escape for nanoparticle mediated siRNA delivery

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Abstract

Gene therapy with siRNA is a promising biotechnology to treat cancer and other diseases. To realize siRNA-based gene therapy, a safe and efficient delivery method is essential. Nanoparticle mediated siRNA delivery is of great importance to overcome biological barriers for systemic delivery in vivo. Based on recent discoveries, endosomal escape is a critical biological barrier to be overcome for siRNA delivery. This feature article focuses on endosomal escape strategies used for nanoparticle mediated siRNA delivery, including cationic polymers, pH sensitive polymers, calcium phosphate, and cell penetrating peptides. Work has been done to develop different endosomal escape strategies based on nanoparticle types, administration routes, and target organ/cell types. Also, enhancement of endosomal escape has been considered along with other aspects of siRNA delivery to ensure target specific accumulation, high cell uptake, and low toxicity. By enhancing endosomal escape and overcoming other biological barriers, great progress has been achieved in nanoparticle mediated siRNA delivery.

Graphical abstract: Enhancing endosomal escape for nanoparticle mediated siRNA delivery

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Article information


Submitted
02 Jan 2014
Accepted
10 Apr 2014
First published
15 Apr 2014

Nanoscale, 2014,6, 6415-6425
Article type
Feature Article

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

D. Ma, Nanoscale, 2014, 6, 6415 DOI: 10.1039/C4NR00018H

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