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Issue 8, 2013
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Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics

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Abstract

In this article, the very recent progress of various functional inorganic nanomaterials is reviewed including their unique properties, surface functionalization strategies, and applications in biosensing and imaging-guided therapeutics. The proper surface functionalization renders them with stability, biocompatibility and functionality in physiological environments, and further enables their targeted use in bioapplications after bioconjugation via selective and specific recognition. The surface-functionalized nanoprobes using the most actively studied nanoparticles (i.e., gold nanoparticles, quantum dots, upconversion nanoparticles, and magnetic nanoparticles) make them an excellent platform for a wide range of bioapplications. With more efforts in recent years, they have been widely developed as labeling probes to detect various biological species such as proteins, nucleic acids and ions, and extensively employed as imaging probes to guide therapeutics such as drug/gene delivery and photothermal/photodynamic therapy.

Graphical abstract: Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics

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Article information


Submitted
09 Dec 2012
Accepted
10 Feb 2013
First published
14 Feb 2013

Nanoscale, 2013,5, 3127-3148
Article type
Review Article

Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics

S. Jiang, K. Y. Win, S. Liu, C. P. Teng, Y. Zheng and M. Han, Nanoscale, 2013, 5, 3127
DOI: 10.1039/C3NR34005H

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