Issue 24, 2013
From the journal:

Nanoscale

Protamine sulfate–nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells†

Minjun Cao,‡a   Xiongwei Deng,‡a   Shishuai Su,b   Fang Zhang,a   Xiangqian Xiao,a   Qin Hu,a   Yongwei Fu,a   Burton B. Yang,c   Yan Wu,*b   Wang Sheng*a  and  Yi Zenga  

* Corresponding authors

a College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Beijing, P.R. China
E-mail: shengwang@bjut.edu.cn

b National Center for Nanoscience and Technology, No.11 Beiyitiao, Zhongguancun, Beijing, P.R. China
E-mail: wuy@nanoctr.cn

c Department of Laboratory Medicine and Pathobiology, University of Toronto, 2075 Bayview Avenue, Toronto, Canada

Abstract

We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)–nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and ΔNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.

Graphical abstract: Protamine sulfate–nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells

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Article information

DOI
https://doi.org/10.1039/C3NR04056A
Article type
Communication
Submitted
04 Aug 2013
Accepted
23 Sep 2013
First published
25 Sep 2013

Nanoscale, 2013,5, 12120-12125

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Protamine sulfate–nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells

M. Cao, X. Deng, S. Su, F. Zhang, X. Xiao, Q. Hu, Y. Fu, B. B. Yang, Y. Wu, W. Sheng and Y. Zeng, Nanoscale, 2013, 5, 12120 DOI: 10.1039/C3NR04056A

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