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Issue 12, 2013

A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

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Abstract

This report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of ∼100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease.

Graphical abstract: A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

Supplementary files

Article information


Submitted
14 Mar 2013
Accepted
10 Apr 2013
First published
12 Apr 2013

Nanoscale, 2013,5, 5262-5265
Article type
Communication

A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

J. Sun, Y. Xianyu, M. Li, W. Liu, L. Zhang, D. Liu, C. Liu, G. Hu and X. Jiang, Nanoscale, 2013, 5, 5262 DOI: 10.1039/C3NR01289A

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