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Issue 8, 2013
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Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging

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Abstract

We report a simple, efficient synthesis of novel 18F-labeled imaging agents based on YF3 nanoparticles. Targeting ligands and antitumor drug molecules can be introduced onto the YF3 nanoparticles in a one-pot synthesis. The 18F-labeling reaction proceeds in aqueous solutions at room temperature with excellent radiolabeling yields (>80%) in a very short time (5–10 min). 18F-labeled YF3 nanoparticles displayed high stability in mouse and human serum, and their application for mapping lymph nodes in live rats after local injection has also been demonstrated.

Graphical abstract: Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging

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Publication details

The article was received on 19 Jan 2013, accepted on 03 Mar 2013 and first published on 19 Mar 2013


Article type: Communication
DOI: 10.1039/C3NR00335C
Citation: Nanoscale, 2013,5, 3253-3256
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    Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging

    L. Xiong, B. Shen, D. Behera, S. S. Gambhir, F. T. Chin and J. Rao, Nanoscale, 2013, 5, 3253
    DOI: 10.1039/C3NR00335C

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