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Issue 8, 2013
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Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging

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Abstract

We have synthesized an efficient and highly sensitive nanoamplifier composed of gadolinium-doped silica nanoparticles and gold nanoparticles (AuNPs). Magnetic resonance imaging (MRI) in vitro and in vivo assays revealed enhancement of signal sensitivity, which may be explained by electron transfer between water and gadolinium-doped nanoparticles, apparent in the presence of gold. In vitro and in vivo evaluation demonstrated nanoamplifier incurred minimal cytotoxicity and immunotoxicity, increased stability, and gradual excretion patterns. Tumor targeted properties were preliminarily determined when the nanoamplifier was injected into mouse models of colon cancer liver metastasis. Furthermore, although AuNPs departed from the nanoamplifiers in specific mice tissues, optical and magnetic resonance imaging was efficient, especially in metastatic tumors. These assays validate our nanoamplifier as an effective MRI signal enhancer with sensitive cancer diagnosis potential.

Graphical abstract: Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging

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Publication details

The article was received on 10 Jan 2013, accepted on 11 Feb 2013 and first published on 14 Feb 2013


Article type: Paper
DOI: 10.1039/C3NR00170A
Nanoscale, 2013,5, 3322-3329

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    Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging

    X. Tian, Y. Shao, H. He, H. Liu, Y. Shen, W. Huang and L. Li, Nanoscale, 2013, 5, 3322
    DOI: 10.1039/C3NR00170A

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