Jump to main content
Jump to site search

Issue 24, 2012
Previous Article Next Article

Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy

Author affiliations

Abstract

Gold nanorods with three different aspect ratios were prepared and their dual capabilities for two-photon imaging and two-photon photodynamic therapy have been demonstrated. These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small organic molecules, which makes them suitable for two-photon imaging. They can also effectively generate singlet oxygen under two-photon excitation, significantly higher than traditional photosensitizers such as Rose Bengal and Indocyanine Green. Such high singlet oxygen generation capability under two-photon excitation was ascribed to their large two-photon absorption cross-sections. Polyvinylpyrrolidone (PVP) coated gold nanorods displayed excellent biocompatibility and high cellular uptake efficiency. The two-photon photodynamic therapy effect and two-photon fluorescence imaging properties of PVP coated gold nanorods have been successfully demonstrated on HeLa cells in vitro using fluorescence microscopy and indirect XTT assay method. These gold nanorods thus hold great promise for imaging guided two-photon photodynamic therapy for the treatment of various malignant tumors.

Graphical abstract: Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy

Back to tab navigation

Supplementary files

Article information


Submitted
08 Aug 2012
Accepted
07 Oct 2012
First published
10 Oct 2012

Nanoscale, 2012,4, 7712-7719
Article type
Paper

Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy

T. Zhao, X. Shen, L. Li, Z. Guan, N. Gao, P. Yuan, S. Q. Yao, Q. Xu and G. Q. Xu, Nanoscale, 2012, 4, 7712
DOI: 10.1039/C2NR32196C

Social activity

Search articles by author

Spotlight

Advertisements