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Issue 9, 2012
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A zwitterion-DNA coating stabilizes nanoparticles against Mg2+ driven aggregation enabling attachment to DNA nanoassemblies

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Abstract

Plasmonics and photonics demand new methods for the controlled construction of nanoparticle (NP) arrays. Complex, low-symmetry configurations of DNA-functionalized NPs are obtained by connection to scaffolds of branched and folded DNA nanostructures. However, the stabilization of these branched structures by Mg2+ counterions also drives the uncontrolled aggregation of NPs. We demonstrate, using a two-dimensional DNA scaffold, that derivatizing gold nanoparticles (AuNPs) with zwitterionic ligands overcomes this problem.

Graphical abstract: A zwitterion-DNA coating stabilizes nanoparticles against Mg2+ driven aggregation enabling attachment to DNA nanoassemblies

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Publication details

The article was received on 28 Feb 2012, accepted on 14 Mar 2012 and first published on 04 Apr 2012


Article type: Communication
DOI: 10.1039/C2NR30479A
Citation: Nanoscale, 2012,4, 2855-2858

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    A zwitterion-DNA coating stabilizes nanoparticles against Mg2+ driven aggregation enabling attachment to DNA nanoassemblies

    T. K. Mudalige, O. Gang and W. B. Sherman, Nanoscale, 2012, 4, 2855
    DOI: 10.1039/C2NR30479A

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