Issue 11, 2012

Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles

Abstract

The advantages of using magnetic mesoporous silica nanoparticles (M-MSNs) in biomedical applications have been widely recognized. However, poor uptake efficiency may hinder the potential of M-MSNs in many applications, such as cell tracking, drug delivery, fluorescence and magnetic resonance imaging. An external magnetic field may improve the cellular uptake efficiency. In this paper, we evaluated the effect of a magnetic field on the uptake of M-MSNs. We found that the internalization of M-MSNs by A549 cancer cells could be accelerated and enhanced by a magnetic field. An endocytosis study indicated that M-MSNs were internalized by A549 cells mainly through an energy-dependent pathway, namely clathrin-induced endocytosis. Transmission electron microscopy showed that M-MSNs were trafficked into lysosomes. With the help of a magnetic field, anticancer drug-loaded M-MSNs induced elevated cancer cell growth inhibition.

Graphical abstract: Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles

Article information

Article type
Paper
Submitted
14 Feb 2012
Accepted
19 Mar 2012
First published
23 Mar 2012

Nanoscale, 2012,4, 3415-3421

Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles

Q. Liu, J. Zhang, W. Xia and H. Gu, Nanoscale, 2012, 4, 3415 DOI: 10.1039/C2NR30352C

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