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Issue 7, 2012
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Functional self-assembled DNA nanostructures for molecular recognition

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Abstract

Nucleic acids present a wonderful toolkit of structural motifs for nanoconstruction. Functional DNA nanostructures can enable protein recognition by the use of aptamers attached to a basic core shape formed by DNA self-assembly. Here, we present a facile, programmable strategy for the assembly of discrete aptamer-tagged DNA shapes and nanostructures that can function for molecular recognition and binding in an aqueous environment. These nanostructures, presented here to bind two different protein targets, are easily synthesized in large numbers, and are portable and stable over long periods of time. This construction modality can facilitate on-demand production of libraries of diverse shapes to recognize and bind proteins or catalyze reactions via functional nucleic acid tags.

Graphical abstract: Functional self-assembled DNA nanostructures for molecular recognition

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Publication details

The article was received on 10 Nov 2011, accepted on 26 Jan 2012 and first published on 30 Jan 2012


Article type: Paper
DOI: 10.1039/C2NR11711H
Nanoscale, 2012,4, 2439-2446

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    Functional self-assembled DNA nanostructures for molecular recognition

    X. Zhang and V. K. Yadavalli, Nanoscale, 2012, 4, 2439
    DOI: 10.1039/C2NR11711H

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