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Issue 4, 2012
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The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy

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Abstract

To determine the effects of biophysical parameters (e.g. charge, hydrophobicity, helicity) of peptides on the mechanism of anticancer activity, we applied a single molecule technique—force spectroscopy based on atomic force microscope (AFM)—to study the interaction force at the single molecule level. The activity of the peptide and analogs against HeLa cells exhibited a strong correlation with the hydrophobicity of peptides. Our results indicated that the action mode between α-helical peptides and cancer cells was largely hydrophobicity-dependent.

Graphical abstract: The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy

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Publication details

The article was received on 19 Oct 2011, accepted on 07 Dec 2011 and first published on 03 Jan 2012


Article type: Communication
DOI: 10.1039/C2NR11541G
Nanoscale, 2012,4, 1283-1286

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    The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy

    Y. Shan, J. Huang, J. Tan, G. Gao, S. Liu, H. Wang and Y. Chen, Nanoscale, 2012, 4, 1283
    DOI: 10.1039/C2NR11541G

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