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Issue 11, 2011
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A fast synthesis of near-infrared emitting CdTe/CdSe quantum dots with small hydrodynamic diameter for in vivo imaging probes

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Abstract

Highly luminescent near-infrared (NIR) emitting CdTe/CdSe quantum dots (QDs) were prepared through a fast and convenient method, and a new type of multivalent polymer ligands was used as the surface substituents to prepare highly stable hydrophilic QDs with small sizes. The well-defined CdTe/CdSe QDs were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), energy dispersive X-ray (EDX) spectroscopy and photoluminescence (PL) spectroscopy, respectively. The as-prepared CdTe/CdSe QDs were photostable with high PL quantum yields (QYs) (up to 66% at room temperature), low toxicity to cells at experimental dosages, and the QDs' fluorescence emissions were tunable between 700 and 820 nm. Furthermore, fluorescence imaging using CdTe/CdSe QDs conjugated with the AS1411 aptamer (targeting nucleolin) probe in cancer cells was reported, and the CdTe/CdSe QDs were also successfully applied for the fluorescence imaging of living animals. Our preliminary results illustrated that the CdTe/CdSe NIR-QDs with small sizes would be an alternative probe for ultrasensitive, multicolor, and multiplex applications, especially for in vivo imaging applications.

Graphical abstract: A fast synthesis of near-infrared emitting CdTe/CdSe quantum dots with small hydrodynamic diameter for in vivo imaging probes

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Article information


Submitted
26 Jul 2011
Accepted
05 Sep 2011
First published
11 Oct 2011

Nanoscale, 2011,3, 4724-4732
Article type
Paper

A fast synthesis of near-infrared emitting CdTe/CdSe quantum dots with small hydrodynamic diameter for in vivo imaging probes

D. Hu, P. Zhang, P. Gong, S. Lian, Y. Lu, D. Gao and L. Cai, Nanoscale, 2011, 3, 4724
DOI: 10.1039/C1NR10933B

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