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Issue 9, 2011
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Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules

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Abstract

We present a method for controlled connection of gold electrodes with dsDNA molecules (locally on a chip) by utilizing polymerase to elongate single-stranded DNA primers attached to the electrodes. Thiol-modified oligonucleotides are directed and immobilized to nanoscale electrodes by means of dielectrophoretic trapping, and extended in a procedure mimicking PCR, finally forming a complete dsDNA molecule bridging the gap between the electrodes. The technique opens up opportunities for building from the bottom-up, for detection and sensing applications, and also for molecular electronics.

Graphical abstract: Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules

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Publication details

The article was received on 20 May 2011, accepted on 23 Jun 2011 and first published on 03 Aug 2011


Article type: Paper
DOI: 10.1039/C1NR10518C
Citation: Nanoscale, 2011,3, 3788-3792
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    Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules

    V. Linko, J. Leppiniemi, B. Shen, E. Niskanen, V. P. Hytönen and J. J. Toppari, Nanoscale, 2011, 3, 3788
    DOI: 10.1039/C1NR10518C

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