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Issue 3, 2011
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New integrated elemental and molecular strategies as a diagnostic tool for the quality of water soluble quantum dots and their bioconjugates

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Abstract

Herein, we demonstrate that both qualitative molecular and quantitative elemental data obtained from size exclusion chromatography coupled online for the first time to both molecular fluorescence and elemental mass spectrometry, respectively, turned out to be critical to evaluate the quality of coatings of quantum dots. Moreover, such an instrumental approach also allowed us to study quantitatively the appropriated bioconjugation of quantum dots to antibodies, a critical step for QDs future use in quantitative fluorescence immunoassays.

Graphical abstract: New integrated elemental and molecular strategies as a diagnostic tool for the quality of water soluble quantum dots and their bioconjugates

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Article information


Submitted
02 Nov 2010
Accepted
15 Dec 2010
First published
14 Jan 2011

Nanoscale, 2011,3, 954-957
Article type
Communication

New integrated elemental and molecular strategies as a diagnostic tool for the quality of water soluble quantum dots and their bioconjugates

L. Trapiella-Alfonso, A. R. Montoro Bustos, J. R. Encinar, J. M. Costa-Fernández, R. Pereiro and A. Sanz-Medel, Nanoscale, 2011, 3, 954
DOI: 10.1039/C0NR00822B

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