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Issue 3, 2011
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Probing the role of aromaticity in the design of dipeptide based nanostructures

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Abstract

Self-assembly of peptide into nanostructures is believed to be stabilized primarily by aromatic interactions. Using a minimalistic approach, we probed the importance of aromatic interactions in the self-assembly of simple model dipeptides. Our results suggest that aromaticity may not be absolutely essential for self-assembly, even though it tends to provide directionality to the assembly. We found that peptides containing cyclic/linear side chain hydrophobic residues were also capable of forming stable self-assemblies that are stabilized by hydrophobic interactions. Our observations will find relevance in the design of small peptide based nanoparticles.

Graphical abstract: Probing the role of aromaticity in the design of dipeptide based nanostructures

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Article information


Submitted
18 Sep 2010
Accepted
05 Dec 2010
First published
11 Jan 2011

Nanoscale, 2011,3, 945-949
Article type
Communication

Probing the role of aromaticity in the design of dipeptide based nanostructures

A. Mishra and V. S. Chauhan, Nanoscale, 2011, 3, 945
DOI: 10.1039/C0NR00691B

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