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Issue 2, 2011
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Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

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Abstract

We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.

Graphical abstract: Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

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Article information


Submitted
23 Jun 2010
Accepted
03 Sep 2010
First published
29 Sep 2010

Nanoscale, 2011,3, 387-390
Article type
Communication

Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

E. Occhipinti, P. Verderio, A. Natalello, E. Galbiati, M. Colombo, S. Mazzucchelli, A. Salvadè, P. Tortora, S. M. Doglia and D. Prosperi, Nanoscale, 2011, 3, 387
DOI: 10.1039/C0NR00436G

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