Issue 12, 2010

Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Abstract

In the present study, the in vivo distribution of polyelectrolyte multilayer coated gold nanoparticles is shown, starting from the living animal down to cellular level. The coating was designed with functional moieties to serve as a potential nano drug for prion disease. With near infrared time-domain imaging we followed the biodistribution in mice up to 7 days after intravenous injection of the nanoparticles. The peak concentration in the head of mice was detected between 19 and 24 h. The precise particle distribution in the brain was studied ex vivo by X-ray microtomography, confocal laser and fluorescence microscopy. We found that the particles mainly accumulate in the hippocampus, thalamus, hypothalamus, and the cerebral cortex.

Graphical abstract: Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Supplementary files

Additions and corrections

Article information

Article type
Paper
Submitted
27 May 2010
Accepted
10 Aug 2010
First published
15 Oct 2010

Nanoscale, 2010,2, 2826-2834

Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

F. Sousa, S. Mandal, C. Garrovo, A. Astolfo, A. Bonifacio, D. Latawiec, R. H. Menk, F. Arfelli, S. Huewel, G. Legname, H. Galla and S. Krol, Nanoscale, 2010, 2, 2826 DOI: 10.1039/C0NR00345J

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