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Issue 3, 2010
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Nanoneedle: A multifunctional tool for biological studies in living cells

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Abstract

Studying biology in living cells is methodologically challenging but highly beneficial. Recent advances in nanobiotechnology offer exciting new opportunities to address this challenge. The nanoneedle technology, as an emerging technology that uses a cell membrane-penetrating nanoneedle to probe and manipulate biological processes in living cells, is expected to play an important role in this endeavor. Here we review the recent development and future direction of the nanoneedle technology for biological studies in living cells. The nanoneedle technology is shown to be powerful and versatile, and can offer numerous new ways to explore biological processes and biophysical properties of living cells with high spatial and temporal precision potentially reaching molecular resolution.

Graphical abstract: Nanoneedle: A multifunctional tool for biological studies in living cells

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Article information


Submitted
21 Aug 2009
Accepted
26 Oct 2009
First published
09 Dec 2009

Nanoscale, 2010,2, 363-372
Article type
Feature Article

Nanoneedle: A multifunctional tool for biological studies in living cells

K. Yum, N. Wang and M. Yu, Nanoscale, 2010, 2, 363
DOI: 10.1039/B9NR00231F

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