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Issue 4, 2021

Polypharmacology of andrographolide: beyond one molecule one target

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Abstract

Covering: 1951 to 2020

Andrographolide is one of the most widely studied plant secondary metabolites, known to display diverse pharmacological actions. Current literature has documented a sizeable list of pharmacological targets for andrographolide, suggesting its multi-targeting nature. Many of these targets are central to the pathophysiology of highly prevalent diseases such as cardiovascular diseases, neurodegenerative disorders, autoimmunity, and even cancer. Despite its well-documented therapeutic efficacy in various disease models, for years, the discrepancies between in vivo bioavailability and bioactivity of andrographolide and the debate surrounding its multi-targeting properties (polypharmacology or promiscuity?) have hindered the development of this versatile molecule into a potential therapeutic agent. Is andrographolide a valuable lead for therapeutic development or a potential invalid metabolic panacea (IMP)? This perspective article aims to discuss this by considering various contributing factors to the polypharmacology of andrographolide.

Graphical abstract: Polypharmacology of andrographolide: beyond one molecule one target

Article information


Submitted
03 Jul 2020
First published
06 Oct 2020

Nat. Prod. Rep., 2021,38, 682-692
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Polypharmacology of andrographolide: beyond one molecule one target

Q. T. N. Tran, W. S. D. Tan, W. S. F. Wong and C. L. L. Chai, Nat. Prod. Rep., 2021, 38, 682 DOI: 10.1039/D0NP00049C

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