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Issue 9, 2019
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Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines

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Abstract

Covering: 2014 to 2019

Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) have been the subject of engineering efforts for multiple decades. Their modular assembly line architecture potentially allows unlocking vast chemical space for biosynthesis. However, attempts thus far are often met with mixed success, due to limited molecular compatibility of the parts used for engineering. Now, new engineering strategies, increases in genomic data, and improved computational tools provide more opportunities for major progress. In this review we highlight some of the challenges and progressive strategies for the re-design of NRPSs & type I PKSs and survey useful computational tools and approaches to attain the ultimate goal of semi-automated and design-based engineering of novel peptide and polyketide products.

Graphical abstract: Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines

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Article information


Submitted
14 Mar 2019
First published
01 Jul 2019

This article is Open Access

Nat. Prod. Rep., 2019,36, 1249-1261
Article type
Review Article

Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines

M. Alanjary, C. Cano-Prieto, H. Gross and M. H. Medema, Nat. Prod. Rep., 2019, 36, 1249
DOI: 10.1039/C9NP00021F

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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