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Issue 7, 2017
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Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

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Abstract

Covering: up to 2017

The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have become increasingly recognised as a rich yet underexplored source of novel antimicrobials, with the potential to combat the looming health threat posed by antibiotic resistance. In this article, we have compiled a comprehensive list of natural products with antimicrobial activity from Gram-negative bacteria, including information on their biosynthetic origin(s) and molecular target(s), where known. We also provide a detailed discussion of several unusual pathways for antibiotic biosynthesis in Gram-negative bacteria, serving to highlight the exceptional biocatalytic repertoire of this group of microorganisms.

Graphical abstract: Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

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Article information


Submitted
31 Jan 2017
First published
26 Jun 2017

Nat. Prod. Rep., 2017,34, 712-783
Article type
Review Article

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

J. Masschelein, M. Jenner and G. L. Challis, Nat. Prod. Rep., 2017, 34, 712
DOI: 10.1039/C7NP00010C

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