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Issue 8, 2016
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Engineering microbial hosts for production of bacterial natural products

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Abstract

Covering up to end 2015

Microbial fermentation provides an attractive alternative to chemical synthesis for the production of structurally complex natural products. In most cases, however, production titers are low and need to be improved for compound characterization and/or commercial production. Owing to advances in functional genomics and genetic engineering technologies, microbial hosts can be engineered to overproduce a desired natural product, greatly accelerating the traditionally time-consuming strain improvement process. This review covers recent developments and challenges in the engineering of native and heterologous microbial hosts for the production of bacterial natural products, focusing on the genetic tools and strategies for strain improvement. Special emphasis is placed on bioactive secondary metabolites from actinomycetes. The considerations for the choice of host systems will also be discussed in this review.

Graphical abstract: Engineering microbial hosts for production of bacterial natural products

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Publication details

The article was received on 01 Feb 2016 and first published on 13 Apr 2016


Article type: Review Article
DOI: 10.1039/C6NP00017G
Nat. Prod. Rep., 2016,33, 963-987

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    Engineering microbial hosts for production of bacterial natural products

    M. M. Zhang, Y. Wang, E. L. Ang and H. Zhao, Nat. Prod. Rep., 2016, 33, 963
    DOI: 10.1039/C6NP00017G

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