Issue 4, 2016

Trends in applying C–H oxidation to the total synthesis of natural products

Abstract

Covering: 2006 to 2015

C–H functionalization remains one of the frontier challenges in organic chemistry and drives quite an active area of research. It has recently been applied in various novel strategies for the synthesis of natural products. It can dramatically increase synthetic efficiency when incorporated into retrosynthetic analyses of complex natural products, making it an essential part of current trends in organic synthesis. In this Review, we focus on selected case studies of recent applications of C–H oxidation methodologies in which the C–H bond has been exploited effectively to construct C–O and C–N bonds in natural product syntheses. Examples of syntheses representing different types of C–H oxidation are discussed to illustrate the potential of this approach and inspire future applications.

Graphical abstract: Trends in applying C–H oxidation to the total synthesis of natural products

Article information

Article type
Review Article
Submitted
30 Sep 2015
First published
05 Feb 2016

Nat. Prod. Rep., 2016,33, 562-581

Author version available

Trends in applying C–H oxidation to the total synthesis of natural products

Y. Qiu and S. Gao, Nat. Prod. Rep., 2016, 33, 562 DOI: 10.1039/C5NP00122F

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