Jump to main content
Jump to site search

Issue 1, 2016
Previous Article Next Article

Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

Author affiliations

Abstract

Covering: 2000 to 2015

While recent breakthroughs in the discovery of peptide antibiotics and other Peptidic Natural Products (PNPs) raise a challenge for developing new algorithms for their analyses, the computational technologies for high-throughput PNP discovery are still lacking. We discuss the computational bottlenecks in analyzing PNPs and review recent advances in genome mining, peptidogenomics, and spectral networks that are now enabling the discovery of new PNPs via mass spectrometry. We further describe the connections between these advances and the new generation of software tools for PNP dereplication, de novo sequencing, and identification.

Graphical abstract: Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

Back to tab navigation

Article information


Submitted
04 May 2015
First published
26 Oct 2015

Nat. Prod. Rep., 2016,33, 73-86
Article type
Review Article
Author version available

Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

H. Mohimani and P. A. Pevzner, Nat. Prod. Rep., 2016, 33, 73
DOI: 10.1039/C5NP00050E

Social activity

Search articles by author

Spotlight

Advertisements