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Issue 11, 2015

Colibactin: understanding an elusive gut bacterial genotoxin

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Abstract

Covering: 2006 to August 2015

This highlight provides an overview of recent progress towards elucidating the structure, biosynthesis, and mode of action of colibactin, a genotoxic secondary metabolite synthesized by human gut bacteria. While isolating colibactin has been problematic, efforts to characterize its biosynthesis have provided critical information that has led to a rapid increase in our knowledge of this metabolite's structure and function. Major questions and gaps remain however, and the broader lessons learned from studying colibactin underscore central challenges to be faced in the genomics era of natural product research and in efforts to understand the human microbiome.

Graphical abstract: Colibactin: understanding an elusive gut bacterial genotoxin

Article information


Submitted
11 Aug 2015
First published
22 Sep 2015

Nat. Prod. Rep., 2015,32, 1534-1540
Article type
Highlight

Colibactin: understanding an elusive gut bacterial genotoxin

E. P. Balskus, Nat. Prod. Rep., 2015, 32, 1534 DOI: 10.1039/C5NP00091B

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