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Issue 5, 2015
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The expanding roles of c-di-GMP in the biosynthesis of exopolysaccharides and secondary metabolites

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Abstract

Covering: up to the end of 2014

The cyclic dinucleotide c-di-GMP has emerged in the last decade as a prevalent intracellular messenger that orchestrates the transition between the motile and sessile lifestyles of many bacterial species. The motile-to-sessile transition is often associated with the formation of extracellular matrix-encased biofilm, an organized community of bacterial cells that often contributes to antibiotic resistance and host–pathogen interaction. It is increasingly clear that c-di-GMP controls motility, biofilm formation and bacterial pathogenicity partially through regulating the production of exopolysaccharides (EPS) and small-molecule secondary metabolites. This review summarizes our current understanding of the regulation of EPS biosynthesis by c-di-GMP in a diversity of bacterial species and highlights the emerging role of c-di-GMP in the biosynthesis of small-molecule secondary metabolites.

Graphical abstract: The expanding roles of c-di-GMP in the biosynthesis of exopolysaccharides and secondary metabolites

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Article information


Submitted
20 Jun 2014
First published
10 Feb 2015

Nat. Prod. Rep., 2015,32, 663-683
Article type
Review Article
Author version available

The expanding roles of c-di-GMP in the biosynthesis of exopolysaccharides and secondary metabolites

Z. Liang, Nat. Prod. Rep., 2015, 32, 663
DOI: 10.1039/C4NP00086B

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