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Issue 4, 2014
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Sequential catalysis for stereoselective synthesis of complex polyketides

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Abstract

Covering: the literature up to 2012

This review presents recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides. These include a novel domino reaction, based on a combination of a nucleophilic addition and a Tsuji–Trost reaction, an innovative sequence relying on an oxidative diyne cyclization and regioselective opening, as well as sequential cross coupling strategies. The design and scope of these methods are discussed and applications in complex target syntheses presented.

Graphical abstract: Sequential catalysis for stereoselective synthesis of complex polyketides

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Publication details

The article was received on 16 Sep 2013 and first published on 23 Dec 2013


Article type: Review Article
DOI: 10.1039/C3NP70093C
Nat. Prod. Rep., 2014,31, 456-467

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    Sequential catalysis for stereoselective synthesis of complex polyketides

    D. Herkommer, B. Schmalzbauer and D. Menche, Nat. Prod. Rep., 2014, 31, 456
    DOI: 10.1039/C3NP70093C

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