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Issue 11, 2013
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Catechin prodrugs and analogs: a new array of chemical entities with improved pharmacological and pharmacokinetic properties

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Abstract

Covering: 2001 to March 2013

Extensive research on tea catechins, mainly (–)-epigallocatechin gallate, has shown numerous health promoting effects. However, various clinical studies demonstrated several issues associated with tea catechins which account for their poor systemic bioavailability. In order to improve pharmacological activity and bioavailability of natural tea catechins, two major strategies have been adopted to date which include synthesizing catechin analogs/prodrugs and the development of novel drug delivery systems. In this review, we provide a detailed account of novel synthetic analogs/prodrugs as well as novel drug delivery approaches used for natural tea catechins to make them therapeutically potent drug-like molecules.

Graphical abstract: Catechin prodrugs and analogs: a new array of chemical entities with improved pharmacological and pharmacokinetic properties

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Publication details

The article was received on 29 Jan 2013 and first published on 17 Sep 2013


Article type: Review Article
DOI: 10.1039/C3NP70038K
Nat. Prod. Rep., 2013,30, 1438-1454

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    Catechin prodrugs and analogs: a new array of chemical entities with improved pharmacological and pharmacokinetic properties

    S. Bansal, S. Vyas, S. Bhattacharya and M. Sharma, Nat. Prod. Rep., 2013, 30, 1438
    DOI: 10.1039/C3NP70038K

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