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Issue 1, 2013
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2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways

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Abstract

Covering: 2007 to September 2012

The 2-deoxystreptamine-containing aminoglycosides, such as neomycin, kanamycin and gentamicin, are an important class of antibiotics. A detailed understanding of the complete biosynthetic pathway of aminoglycosides and their biosynthetic enzymes will allow us to not only generate more robust antibiotic agents or drugs with other altered biological activities, but also to produce clinically important semi-synthetic antibiotics by direct fermentation. This Highlight focuses on recent advances in the characterization of their biosynthetic enzymes and pathway as well as some chemo-enzymatic and metabolic engineering approaches for the biological production of natural, semi-synthetic, and novel aminoglycosides.

Graphical abstract: 2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways

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Publication details

The article was received on 10 Sep 2012 and first published on 26 Nov 2012


Article type: Highlight
DOI: 10.1039/C2NP20092A
Nat. Prod. Rep., 2013,30, 11-20

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    2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways

    S. R. Park, J. W. Park, Y. H. Ban, J. K. Sohng and Y. J. Yoon, Nat. Prod. Rep., 2013, 30, 11
    DOI: 10.1039/C2NP20092A

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