Issue 12, 2012
From the journal:

Natural Product Reports

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

Jorge A. R. Salvador,*ab   Vânia M. Moreira,ac   Bruno M. F. Gonçalves,ab   Ana S. Lealab  and  Yongkui Jing*d  

* Corresponding authors

a Grupo de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
E-mail: salvador@ci.uc.pt
Fax: +351 239827126
Tel: +351 239488479

b Centro Neurociências e Biologia Celular, Universidade de Coimbra, 3004-517 Coimbra, Portugal

c Centre of Chemistry, Faculty of Sciences and Technology, University of Coimbra, Portugal

d Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
E-mail: yongkui.jing@mssm.edu

Abstract

Covering: up to December 2011

This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.

Graphical abstract: Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C2NP20060K
Article type
Review Article
Submitted
04 May 2012
First published
09 Oct 2012

Nat. Prod. Rep., 2012,29, 1463-1479

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Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

J. A. R. Salvador, V. M. Moreira, B. M. F. Gonçalves, A. S. Leal and Y. Jing, Nat. Prod. Rep., 2012, 29, 1463 DOI: 10.1039/C2NP20060K

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