Issue 5, 2012
From the journal:

Natural Product Reports

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation

Yukari Fujimoto,*a   Ambara Rachmat Pradipta,a   Naohiro Inoharab  and  Koichi Fukasea  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan
E-mail: yukarif@chem.sci.osaka-u.ac.jp
Fax: +81-6-6850-5419
Tel: +81-6-6850-5391

b Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA

Abstract

Covering: up to 2011

This review focuses on the recent revealing of the immunostimulatory bacterial cell wall peptidoglycan (PGN) fragments as Nod1 ligands, especially a newly developed chemical synthesis of the partial structures, fragment structures in the environment and bacterial supernatant, and the immunostimulatory activities of the Nod1 ligands.

Graphical abstract: Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation

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Article information

DOI
https://doi.org/10.1039/C2NP00091A
Article type
Review Article
Submitted
10 Nov 2011
First published
28 Feb 2012

Nat. Prod. Rep., 2012,29, 568-579

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Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation

Y. Fujimoto, A. R. Pradipta, N. Inohara and K. Fukase, Nat. Prod. Rep., 2012, 29, 568 DOI: 10.1039/C2NP00091A

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