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Issue 1, 2012
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Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

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Abstract

Covering: up through August 2011

This review covers the emerging biosynthetic role of crotonyl-CoA carboxylase/reductase (CCR) homologs in extending the structural and functional diversity of polyketide natural products. CCRs catalyze the reductive carboxylation of α,β-unsaturated acyl-CoA substrates to produce a variety of substituted malonyl-CoA derivatives employed as polyketide synthase extender units. Here we discuss the history of CCRs in both primary and secondary metabolism, the mechanism by which they function, examples of new polyketide diversity from pathway specific CCRs, and the role of CCRs in facilitating the bioengineering novel polyketides.

Graphical abstract: Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

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Publication details

The article was received on 18 Oct 2011 and first published on 29 Nov 2011


Article type: Review Article
DOI: 10.1039/C1NP00082A
Nat. Prod. Rep., 2012,29, 72-86

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    Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

    M. C. Wilson and B. S. Moore, Nat. Prod. Rep., 2012, 29, 72
    DOI: 10.1039/C1NP00082A

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